I B.Pharmacy Regular Examination,June 2008.PHYSICAL PHARMACY I

1 a)What are the different gas laws ? Define and derive their equations.
b)Write different methods of liquefaction of gases.

2 a)Define the law of thermodynamics.
b)What is the significance of entropy in thermodynamics.

3 a)Write construction and working of Abbe Refractometer?
b)Define molar refraction and write its applications.

4 What do you meant by Solutions of Non electrolytes.Explain.

5 a) Write about Van't Hoff Theory of Solutions in detail.
b) What is meant by Equivalent conductance.

6 a)Define and discuss acid-base equilibria.
b)Explain different modern theories to explain acids,bases and salts.

7 a)Write in detail Buffer Action-Mechanisms.
b)Write in detail on Henderson-Hasselbalch Equation.

8 Explain the methodology in the construction of Electrochemical Cells.
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I B.Pharmacy Regular Examination,June 2008.ANATOMY AND PHYSIOLOGY


1 a) What are epithelial cells ? Classify them and Write their functions.
b) Define tissue.Write about connective tissue cells.

2 a) Write the composition of the blood with its normal values and explain how it is
altered in the pathophysiological state.
b) Write a note on structure of RBC and its functions.

3 a) What are the different valves of heart?Write its functions?
b) Write a note on blood pressure.

4 a) Write the different types of movement occuring in the GI tract.
b) Give an account of physiology of oral cavity.

5 a) Explain the Anatomy and Physiology of pulmonary circulation.
b) Write a note on mechanism of respiration.

6 a) Enumerate the chemical substance involved in synaptic transmission.
b) Write about anatomy and physiology of thalamus

7 a) Write about the compositions of urine.Explain the pathway of urine flow.
b) Write a note on ureters.

8 a) What are the effects of 'Thyroid' hormone on different parts of the body ?
b) Discuss about anatomy of thyroid gland.
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I B.Pharmacy Regular Examination,June 2008.PHARMACEUTICAL ORGANIC CHEMISTRY I


1 (a) Write short notes on tautomerization rections.
(b) Write short notes on :
Inductive effect.
Mesomeric effect



Resonance

Hyper conjucation

2 (a) What are aldehydes and ketones ? Write any three methods of prepartion and three
important reactions for each of them.
(b) What are conjugated dienes ? Explain the formation of 1:4 addition product in
dienes.

3 (a) Explain in detail Huckle's rule for aromaticity with the help of examples.
(b) Discuss Birch reduction and two important reactions of polynuclear compounds.

4 (a) Discuss the mechanism of elimination reaction of aliphatic halogen compounds
and explain its stereochemistry.
(b) What is benzyne concept ? Explaian its mechanism.

5 (a) Discuss in detail by taking suitable examples the important rearrangement
reactions involving carbon-nitrogen migration. Also comment on the mechanism.
(b) Explain Meerwein-pondroff verley reduction.

6 What are aldehydes and ketones ? Write any three important methods of prepartion
and reaction mechanism of aldol condensation,cannizzaro reaction.

7 Write a detail note about any four synthesis using aceto acetic ester,malonic
ester and its applications.

8 (a) Explain the considering inductive effects compare the basicity of methylamine
and butylamine.
(b) Discuss reductive reactions of aromatic nitro compounds.
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I B.Pharmacy Regular Examination,June 2008.ENGLISH LANGUAGE COMMUNICATION SKILLS


1 (a) What was the disaster that struck the photograph ? What was Dutta's reaction to
the disaster ?

2 Explain the following positions of articulation.
a. Bilabial
b. Labio-dental
c. Dental
d. Alveolar

3. Imagine that you are a safety Engineer of a car manufacturing factory.There has been a fire accident in the factory and one of the workers has been badly hurt and is in the hospital.Your General Manager has asked you to send him a detailed report on the accident together with your recommendations for averting a similar accident in the future.Prepare a report accordingly.

4. Prepare the following passages for reading by marking tone group boundaries,and the accent and intonation.
He was a difficult child indeed.What had his parents not done to correct him!But the result was anything satisfactory .He was disobedient and rude,and sometimes even violent.At home he was a terror to his younger brother and sister,who often complianed of his cruelty.At school he was a bully of the worst kind.His classmates and his juniors were mortally afraid of him,and his teachers,one and all,complained of his rudeness and even arrogance.The Headmaster,finding himself under great pressure from both his students and colleagues,bundled him out one day,leaving his parents alone to bear the brunt of his madness.

5.From the story "A Service of Love"-Art or Love -which is more important?

6.(a) Write a short note on Fourth Estate.
(b) what do you know about press freedom day?What did the author remember while writing about it?

7. As the sports secretary of your college,write a report on the Annual Sports Day event that took place in your college.

8. Make Antonyms of the following words by adding suitable prefixes:

approve,connect,function,legible,conventional,soph isticated,social,
conduct,balnce,permeable,generate,reversible,consi stent,mobile,significant,
forestation.
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I B.Pharmacy Regular Examination,June 2008.REMEDIAL BIOLOGY


1. (a) Describe the structure,chemical composition,types and functions of DNA.
(b) Write the difference between DNA and RNA

2. Describe the structure and functions of special tissues?

3. Describe the different techniques used for section cutting of a crude drug.

4. Describe the various types of aerial root modification ?

5.With the help of neat labelled diagrams describe the structure and life-history of
Entamoeba histolytica.

6.Give an account of the life history of schistosoma. Draw neat labeled diagram of the same.write a notes on pathogenicity.

7.Write a short notes on :
(a)Body wall
(b)Endo skeleton of cockroach
(c)Fat bodies
(d)Locomotion

8. Explain the mouth parts of Adult culex mosquito.Draw diagram of the same.
write a note on the feeding habit and the diseases caused by mosquito.
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I B.Pharmacy Regular Examinations,June 2008.PHARMACEUTICAL INORGANIC CHEMISTRY


1 (a) Write account on sources of impurities for any three compounds.
(b) Discuss about the qualitative tests for anions and cations.

2 (a) Write preparation,assay and uses of any two calcium compounds.
(b) write a note on Radiopharmaceuticals.

3.Write detail account on the test for Neutralising capacity of wet and dried Aluminium Hydroxide Gel and its applications.

4. Write brief notes on the prepartion,assay principle ,limit tests and appliction of iodine and Iodides.

5. Write in detail the preparation and applicatios of copper sulphate and its medicinal uses.

6. How do you prepare Boric acid from Borax? Write the principle involved in the assay of Boric acid and applications.

7. Discuss about the preparation,assay principle ,limit tests and uses of any two Dental products.

8. Write an essay about the Sodium aurothiomalate and its applications.
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II B.Pharmacy I Semester Regular Examination,November 2008.PHARMACEUTICAL UNIT OPERATION-I


1. What is equilibrium state in a rate process.Give the equilibrium constants.

2. Describe the construction,working,specifications,advantages and limitations of following valves
(a) Globe valves
(b) Diaphram valves

3. Discuss briefly about working and applications of the following pumps.
(a) Gear pumps.
(b) Peristalitic pumps.

4. (a) Describe the construction and working of sintered glass filters.
(b) Compare plate and frame filter press with rotary centrifuge filters.

5.Define the following terms :
(a) Amorphous Solids.
(b) Ploymorphs.
(c) Meta Stable Polymorphs.

6. Write short notes on following :
(a) Applications of Air-conditioning.
(b) Approaches for achieving Air-Conditioning.

7. Write the following:
(a) Deascribe fluid corrosion.
(b) Explian about specific site corrosion.

8. Give a brief account on hazards in Pharmaceutical industry and the preventive safety measures.
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II B.Pharmacy I Semester Regular Examination,November 2008.PHARMACEUTICAL ORGANIC CHEMISTRY-II


1. What happens when :-
(a) Pyrrole is treated with H2,Ni, at 250 degree centigardes.
(b) Discuss the structure & Nomenclature of Pyrrole.

2. Explain the following : 4-bromo-1-Methyl Imidazole treated with n-BuLi/-78 degree centigardes than DMF give C5H6N2O Carrying out the same sequence but allowing the solution to warm to 0 degree centigardes before addition of DMF gave an isomeric product.

3. What are conformational isomers/Illustrate your answer using ethane & cyclohexane as example?

4. (a)Discuss the objectives advanced aganist open chain formula of glucose
(b)How does the ring structure in general overcome the objections
(c)Deduce the nature of the ring.

5. (a) Define and classify amino acids with suitable examples.
(b) How do proteins undergo denaturation? Add a note on Pharmaceutical importance of amino acids .

6. (a) List out the important cardiac glycosides with structures and add a note on the properties and actions of glycone and aglycone parts respectively.
(b)How do you distinguish oils and fats.Define saponification vcalue,acid value and iodine values and their significance.

7. (a) Write the structure for four purine derivatives,and mention their major therapeutic applications
(b) Give a detailed account on the structures of DNA & RNA.

8.Write the mechanism and synthetic applications for the following
(a) Michael addition reaction
(b) Mannich reaction.
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II B.Pharmacy I Semester Regular Examination,November 2008.PHYSICAL PHARMACY-II


1. Discuss how presure,temperature,presence of salt and chemical recation can affect the solubility of gases in liquids.

2. Write on the following :
(a) Determination of stability constnat for complexes by distribution method and solubility method.
(b) Self-association of drugs.

3. Explain first-order reaction citing a suitable example.Derive the equation to calculate the first-order rate constnat.Describe first-order kinetics with the help of a curve.

4.(a) State and exlain "surface tension" and "interfacial tension" at the liquid interface.
(b) What is surface free energy? Explain how it is related to surface tension.

5. (a) Discuss in detail about the pharmaceutical applications on micromeritics
(b) Write a short note on different parameters used to express particle size.

6.(a) Explain the plastic and pseudo plastic behaviour of the materials with the help of flow curves and specific examples?
(b) Differentiate between Newtonian and Non Newtonian systems with suitable exaples?

7.(a) Classify the collodial systems according to states of matter ?
(b) Define Schuiz Hardy rule ? What are its applications ?

8.(a) Define emulgents.What are the desirable properties of an emulsifying agents ?
(b) Discuss the importance and mention the factors affecting the emulsion viscosity.
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II B.Pharmacy I Semester Regular Examination,November 2008.HEALTH EDUCATION AND PATHOPHYSIOLOGY


1. (a) Write about the importance of proteins in the body & discuss the deficiency disorders.
(b) Describe the sources of vitamins and their deficiency disorders.

2. Write briefly about
(a) Significance of Family planning.
(b) Permanent methods of Family planning.
(c) Temporary methods of Family planning.

3. Write the causative agents,modes of transmission and prevention of
(a) Typhoid.
(b) Malaria.
(c) Filariasis.
(d) Rabies.

4.(a) Write about Cardiopulmonary resuscitation.
(b) Deacribe the first aid given in shock & snakebites.

5. Write about :
(a) Fertilization
(b) Sex differentiation
(c) Ogenesis.

6. (a) Discuss and differentiate necrosis and Apoptosis.
(b) Explain about atrophy as a cellular adaptation.

7. (a) Write about the vascular events incase of acute inflammation.
(b) Briefly outline the process of Repair.

8. Write the Pathophysiology of
(a) Peptic ulcer.
(b) Hypertension.
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II B.Pharmacy I Semester Regular Examination,November 2008.STATISTICAL METHOD AND COMPUTER APPLICATION


1. A sales tax office has reported that average sales of the 500 business that he has to deal with during a year is Rs.36,000 with a standard deviation of 10,000 assuming that the sales in these business are normally distributed,find
(a) The number of business has the sales of which are Rs 40,000.
(b) The percentage of business the sale of which are likely to range between Rs 30,000 and Rs 40,000.

2. Find carl pearson's coefficient of correlation in the following series relating to prices and supply of a commodity: 
Price(Rs) 8 10 15 17 20 22 24 25
Supply 25 30 32 35 37 40 42 45

3. From the data given below find out whether the means of three samples differ significantly or not. 

Sample 1 Sample 2 Sample 3
20 19 13
10 13 12
17 17 10
17 12 15
16 9 5

4. (a) Expalin about randomized complete block design (RBD)
(b) Three varieties A,B and C of mungbean are tested in a randomized block design with four replications.The plot yield in pounds are as follows. 
A 6 C 5 A 8 B 9
C 8 A 4 B 6 C 9
B 7 B 6 C 10 A 6
analyse the experimental yoeld and state your conclusion.

5. (a) Define a computer
(b) Explain uses and characteristics of computer.

6. Compare and contrast packages an Application program.

7. (a)Define Arrays and its type.
(b)Write a C program to find the matrix multiplication of a 3*3 matrix.

8.(a) Define the terms Bio-Technology and Bio-Engineering.
(b) Explain the role of computers in Pharmaceutical applications.
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JNTU HYD IV B.Pharmacy I Semester Regular Examinations, November 2008 BIOPHARMACEUTICS AND PHARMACOKINETICS


1. Discuss the role of pharmacokinetics in designing a dosage form. (16)

2. Give an account of various mechanisms of drug absorption across cell
membrane. (16)

3. Write an essay on distribution of drugs in central neivoua system. (16)

4. (a) When is drug binding irreversible
(b) What is the therapeutic implication in such irreversible binding. (8+8)

5. Write a note on:
(a) compartment models.
(b) michaclis-menten equation.

6. (a) Describe the scope of clinical pharmacokinctics with suitable examples
(b) Explain how to adjust the dose in patient with and without Hepatic failure
[8+8]

7. Define Bioavailability. Explain various measurements of Bioavailability. (16)

8. What is Bioequivalence? Give design of simple dose bioequivalence study
with suitable examples.(16) 

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JNTU HYD IV B.Pharmacy I Semester Regular Examinations, November 2008 PHARMACY ADMINISTRATION


1. (a) Define Cooperative society. What are its features?
(b) Write a brief note on Consumers’ cooperative societies. [8+8]

2. Write short notes on
(a) EOQ
(b) VED
(c) Quality Control
(d) Plant layout. (4+4+4+4)

3. Define Air pollution List the nature of air pollution and its adverse effects on
environment. (16)

4. (a) Define Foreign Tade. Write the procedure for export of goods.
(b) What are the advantages and limitations of international trade? (8+8)

5. Explain the special provisions regarding the location of pharmaceutical
industry? (16)

6. Write about the export and import of drugs and pharmaceuticals in India?
[16J

7. Mention the panel and board of members of Pharmaceutical Experts
Association (PEXA). (16)

8. Explain in detail about the Structure or layout of a drug store? (16) 

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JNTU HYD IV B. Pharmacy I SEMESTER Supplementary Examinations, Aug/Sep-2008. Biopharmaceutics & Pharmacokinetics


1.a) Define Bio-pharmaceutics & Pharmacokinetics and give the importance in
formulation development.
b) Define Absorption. Differentiate active and passive transport of drugs.

2.a) Give the importance of particle size, Dissolution rate and pK., on
absorption of drugs.
b) Explain the mechanism of absorption of following compounds.
i) Insulin ii) Vitamin B12.

3.a) What are the factors which effect protein binding and give its clinical
significance.
b) A drug when administered at a dose of 50mg showed an initial concentration
of 0.5mg/ml. Given the half life of the drug 1 .5hr, what is the total clearance of
the drug?

4.a) Write in detail about compartment modelling.
b) What is Mean Residence Time”. Give its significance.

5.a) Mention Various PH-kinetic parameters that can be assessed following oral
administration of a drug.
b) Define absorption rate constant. Discuss the methods to determine absorption
rate constant and its significance.

6. Discuss the significance of Non-linear pharmacokinetjcs with reference to
one compartment model after IV administration and explain the detection of
Non-linearity.

7. What is clinical pharmacokinetics. Discuss the dosage adjustment in patients
with and without Renal & Heptic failure.

8.a) Define Absolute and Relative Bioavailability.
b) Discuss in detail the Bioavailability study protocol. 

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JNTU HYD IV B.Pharmacy I SEMESTER Supplementary Examinations, Aug/Sep-2008. MEDICINAL CHEMISTRY


I .a) What are the advantages and limitations of QSAR?
b) Explain the importance of isomerism. With the help of few examples. in drug
action.

2.a) Discuss drug — receptor interaction. What is transduction mechanism?
b) Write about CADD and molecular modelling.

3.a.) Explain the classification of drugs on the basis of their therapeutic actions.
b) Write about the mechanism of action of prostaglandins.

4.a) Describe the synthetic procedures of any two important adrenergic drugs?
b) Give their mode of action, structure activity relationships and uses.

5 Define antihistamines. Explain their mode of action, structure activity
relationships and uses.

6. Write notes on
a) Eicosanoids
b) Neuromuscular blocking agents.

7. Classify analgesic and antipyretic drugs, with suitable examples. Discuss their
mechanism of action. Write the synthesis of any two agents of this class.

8. Write the structure and therapeutic uses of the following drugs:
a) Atropine b) Ephedrine HCI
c) Chlorpheniramine d) Paracetamol
e) Papaverine Hcl f) Propranolol HCI g) Oxvtocjn.